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العنوان
Changes in fascia structure after induced muscle strain in rodents /
المؤلف
Nagwa Abuelwafa Ibrahim Hassan ,
هيئة الاعداد
باحث / Nagwa AbuElwafa Ibrahim Hassan
مشرف / Aliaa Mohammed Rehan Youssef
مشرف / Nabila Salah Hassan
مناقش / Nadia Abdelazeim
مناقش / Amr Abdallah Azzam
الموضوع
Physical Therapy
تاريخ النشر
2022.
عدد الصفحات
144 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلاج الطبيعي والرياضة والعلاج وإعادة التأهيل
تاريخ الإجازة
25/7/2022
مكان الإجازة
جامعة القاهرة - علاج طبيعي - Musculoskeletal Disorders and their Surgeries
الفهرس
Only 14 pages are availabe for public view

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from 143

Abstract

Background: Recurrence following muscle strain is a serious problem encountered in sports. Muscle and fascia are mechanically integrated in transmitting muscular force. Fascial injury has been associated with muscle strain which may explain its potential contribution to impaired muscle recovery. Purpose: This study aimed at describing structural changes of fascia and muscle as well as limb functional recovery through the various healing stages following strain injury in rodents. Animals: Thirty-two adult (7-9 weeks) male healthy Wistar rats weighting between 203- 282 g (mean ± SD: 234 ± 22). Methods: rats were randomly and equally divided into four groups: normal control and three muscle strain injury groups. Tibialis Anterior muscle was strained in the three injured groups then all rats were allowed free cage mobility until euthanasia after 2 days (acute group), 9 days (subacute group), or 21 days (chronic and normal groups). The sciatic function index was used to assess limb functional recovery while histopathology scoring and histomorphometry quantified tissue healing. Results: Compared to normal control group, cellularity significantly increased in muscle and fascial tissues only in the acute stage (p<0.05). Collagen degeneration was significant in the acute and subacute stages in muscle (p<0.05), whereas fascia showed significant degeneration only at the subacute stage (p<0.05). Fascia thickness significantly increased in all examined stages (p<0.05), while muscle fibers width and interstitial dilatation increased only in the acute and subacute stages (p<0.05). Muscle fibrosis was significant in the subacute and chronic stages (p<0.05). Function was not significantly different between all groups at all examined stages (p>0.05). Conclusions: Strain injury affects all fascia and muscle structures. Healing of all examined structures occurs spontaneously by the chronic stage, except for fascia thickness and muscle fibrosis. Future studies are recommended to investigate whether incorporating fascia as a therapeutic goal would decrease muscle injury recurrence