الفهرس 
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Abstract
The present clinical trial was carried out on Forty client-owned
dogs status ASA I-II. Dogs were randomly allocated into four equal
groups (n = 10). According to the dose of dexmedetomidine in the
premedication. D1MA (dexmedetomidine 1mcg/Kg-methadone
0.3mg/Kg-alfaxalone 1mg/kg), D2MA (dexmedetomidine 2mcg/Kgmethadone
0.3mg/Kg- alfaxalone 1mg/kg), D3MA (dexmedetomidine
3mcg/Kg-methadone 0.3mg/Kg- alfaxalone 1mg/kg), D4MS
(dexmedetomidine 4mcg/Kg-methadone 0.3mg/Kg- NaCl 0.9% 0.1ml/Kg
as control). Cardiorespiratory parameters, biochemical analysis
(including glucose level, and Serum cortisol level), recumbency time, and
sedation score were evaluated at times 5,10,15, and 20 minutes after
premedication. Induction of general anesthesia was performed with
alfaxalone administered intravenously to effect at a rate of (0.5 mg/kg)
with an additional 25% of alfaxalone (0.125 mg/kg) administered as a
bolus every 6 seconds upon request until endotracheal intubation
performed. the required dose to achieve tracheal intubation was recorded.
Anesthesia was maintained with isoflurane in oxygen. Quality of
induction and post-induction Apnea were recorded.
The results of the present study found that, Respiratory rate showed
a significant decrease At T10 (p = 0. 028). The difference was observedin relation between groups D1MA - D4MS (p = 0.005) , D2MA - D4MS
(p= 0.014 ) and D3MA - D4MS (p= 0.049). while systolic, Mean, and
diastolic arterial blood pressure showed a significant difference at T10
with lower values at D1MA compared to D3MA (p = 0.006) and D4MS (p
= 0.04). In the degree of sedation, there were significantly differences
appeared at the time 5 minutes between groups (p= 0.009), This
significance appears between group D1MA - D2MA (p = 0.024), group
D1MA - D3MA (p=0.004), and group D1MA - D4MS (p = 0.012). In
biochemical analysis, Serum cortisol level showed lower levels in D1MA
group among all groups [1.72 ( 0.88-2.84)]. And in Alfaxalone induction
dose although no significant difference between groups but induction
dose showed the lowest dose in D3MA group (0.562 ± 0.106 mg/kg)
In conclusion, adding alfaxalone at a dose of 1 mg/kg to
standard premedication protocol (4 mcg/kg dexmedetomidine + 0.3
mg/kg methadone) reduced the dexmedetomidine dose with the same
sedation quality that overcome the adverse cardiorespiratory effects of the
high dose of dexmedetomidine, lowering the anaesthetic-surgical stress
response, and decrease the anaesthetic induction dose in unpremedicated
dogs.
The study stated that the use of D2MA ( 1 mcg/kg alfaxalone + 2
mcg/kg dexmedetomidine + 0.3 mg/kg methadone) is the ideal
premedication protocol in ASA I – II dogs.