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العنوان
Analytical Quality Assessment of Some Pain Killers in Multicomponent Pharmaceutical Formulations /
المؤلف
Engy Ashraf Ibrahim Mohamed El-Shemy،
هيئة الاعداد
باحث / Engy Ashraf Ibrahim Mohamed El-Shemy
مشرف / Maha Abdel-Monem Hegazy
مشرف / Hoda Allah Mohamed Marzouk
مشرف / Samah Sabry Saad
مناقش / Laila El-Sayed Abdel-Fattah
تاريخ النشر
2022.
عدد الصفحات
129 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
العلوم الصيدلية
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 155

Abstract

This thesis is concerned with the quantitative analysis of some drugs in multi-component pharmaceutical formulations used to alleviate pain, namely; paracetamol co-formulated with caffeine, ergotamine tartrate, and metoclopramide hydrochloride, and paracetamol, aspirin co-formulated with diphenhydramine hydrochloride. Also, the analytical methods involved paracetamol impurities, namely; p-aminophenol and p-nitrophenol, as well as theophylline as caffeine impurity, and salicylic acid as aspirin impurity.
This study aims to design simple, robust, accurate, eco-friendly, and economic analytical approaches for analysis of the cited drugs in their pure powdered forms, combined pharmaceutical formulations in presence of their degradation products or impurities and/or in different biological matrices.
Chapter I General Introduction and Literature Review.
Chapter II Greenness Profile Assessment of selective Liquid chromatographic Methods for Determination of a Quaternary Anti-migraine Combination Along with Three of Their Related Official Impurities.
Chapter III A Reliable Electrochemical Sensor Based on Functionalized Magnetite Nanoparticles for Over-the-counter Allergy Medication Abuse Sensing in Biological Fluids.
Chapter IV Sustainable Liquid chromatographic Determination and Purity Assessment of a Possible Add-on Triple-Action Over-the-counter Pharmaceutical Combination in COVID-19.
Chapter V Resolution of Spectrally Overlapping signals of Paracetamol, Aspirin, and Diphenhydramine in their combined Over-the-counter Pharmaceutical Formulation: Application to Content Uniformity Testing.
Chapter VI General Conclusion
This thesis is divided into six chapters and ended with a list of references, and a summary in Arabic. The six chapters are: