الفهرس 
Evaluation of Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with chronic Peri-apical Periodontitis. A Randomized Clinical Trial
Evaluation of Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with chronic Peri-apical Periodontitis. A Randomized Clinical TrialOnly 14 pages are availabe for public view
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Abstract
Aim: to compare the post-operative pain intensity following platelet rich plasma (PRP)
revascularization in comparison to non-surgical root canal treatment procedures in mature necrotic
mandibular molar teeth with randomized clinical trial.
Methods: Twenty-eight patients were included. After confirming the diagnosis clinically and
radiographically, In the first visit, teeth of both groups were instrumented using ProTaper Next rotary
files. Double antibiotic paste (DAP) was prepared and injected then the cavity was temporarily sealed
with glass ionomer. At the second visit, three weeks later, the patients were assigned according to the
randomization either to control group where standard endodontic treatment was completed by lateral
condensation technique with resin sealer for obturation or assigned to intervention group where PRP
revascularization technique. The degree of spontaneous pain was measured using numerical rating
scale (NRS) pre-operatively, then post-operatively after 6, 12 hours and daily for 5 days. Patients were
given a placebo to be administrated in case of emergency and an analgesic (ibuprofen 400mg) was
prescribed in case of persistent pain. Flare-up was considered if the patients reported moderate to
severe pain and/or swelling that began 12 to 48 hours after treatment and lasted at least 48 hours. All
demographic, baseline and outcome data were collected and statistically analyzedResults: Results showed that, regarding the post instrumentation pain there was no statistically
significant difference concerning severity of pain in the two groups at all time intervals. While in the
post revascularization / obturation pain there was no statistically significant difference between severity
of pain in the two groups at all time intervals except after 12 hours. Revascularization group showed
statistically significantly higher prevalence of no pain than endodontic treatment group (P-value =
0.041). Regarding the healing rate; there was no statistically significant difference between median
lesion areas in the two groups pre-operatively, after 6 as well as 12 months at both mesial and distal
roots.
Conclusions:. Winthin the limitation of this study , It can be concluded that PRP
revascularization reduces the postoperative pain of necrotic mature permanent mandibular molar teeth
with chronic peri-apical periodontitis in comparison to the post-operative pain after conventional
endodontic treatment The healing rate showed that there was no statistically significant difference
between median lesion areas in the two groups pre-operatively, after 6 as well as 12 months at both
mesial and distal roots so PRP revascularization could be a promising alternative to endodontic
treatment in the treatment of necrotic mature permanent mandibular molar teeth with chronic periapical periodontitis