الفهرس 
Pharmaceutical studies on nanocarriers as delivery systems for treatment of alopecia
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Abstract
Abstract
Aminexil is one of non-hormonal peripheral vasodilators, used as anti-hair loss agent that was described for treatment of alopecia. It accelerates new hair growth by working on the deep structure of roots through increasing nutrients, oxygen supply and dilatation of blood vessels. In addition, it helps in regrowthing of lost hair.
Caffeine is an alkaloid that is architecturally interrelated to adenosine and primarily acts as an adenosine receptor antagonist with anti-inflammatory and psychotropic activities. Caffeine has been revealed valuable effects on androgenic alopecia due to an impact on hair growth stimulating and hair loss preventing. It acts as 5-α-reductase inhibitor, thus, prevents testosterone conversion to Dihydrotestosterone (DHT). DHT is the key reason for hair loss for patients who suffer from androgenic alopecia. Caffeine also acts as vasodilator thus increasing blood supply to hair follicles and stimulating hair growth.
Aminexil is water soluble drug and has a water solubility of 33mg/ml, pKa of 4.61 and logP of 1.24. Caffeine is weakly basic drug that has high water solubility of 20 mg/ml, pKa of 10.4 and logP of -0.07.These two drugs are examples of hydrophilic drug model with poor skin permeability.
The main objective of this thesis is to develop successful nanostructured lipid carriers (NLCs) of aminexil and caffeine through utilizing of 23 full factorial design to improve their permeability and fulfill effective therapeutic needs for patients after topical application for alopecia treatment. The prepared NLC formulas were evaluated through many physicochemical characteristics including; entrapment efficiency determination, particle size analysis, zeta potential measurement, electroconductivity study, transmission electron microscopy studies (TEM), in-vitro drug release and ex-vivo permeation study. Finally, the histopathologically studies were carried out to evaluate the hair growth efficacy of these systems