الفهرس 
A pharmaceutical study on antibiotic drug delivery systems for local application in the oral cavity
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Abstract
Periodontal disease is a general term which includes several pathological conditions affecting the tooth supporting structures and characterized by a destruction of the periodontal ligament, a resorption of the alveolar bone and the migration of the junctional epithelium along the tooth surface. It is a localized inflammatory response caused by bacterial infection of a periodontal pocket associated with subgingival plaque that mainly includes chronic periodontitis and aggressive periodontitis. Periodontal disease is the result of a local bacterial infection with apathogenic microflora within the periodontal pocket. The microflora found in periodontitis is complex and composed mainly of gram-negative anaerobic bacteria. Scaling and root planing (SRP) remains the {u2018}gold standard{u2019} as the non-surgical treatment of chronic periodontitis. SRP may, however, fail to reduce or eliminate the anaerobic infection at the base of the pocket, within the gingival tissue or in furcations which in turn may serve as reservoirs for periodontopathic bacteria from which re-colonization of treated root surfaces can occur. The bacterial reservoir which is inaccessible for by mechanical debridement alone can be further eliminated with the adjunctive use of chemotherapeutic agents.