الفهرس Only 14 pages are availabe for public view
 |  | from | 139 |  |  |
| | | from | 139 | | |
Abstract
Aim of work This study was conducted to evaluate the histomorphology of the placenta and the placental bed and to correlate this with Doppler studies of both uterine and umbilical arteries of severe preeclamptic patients complicated by growth restricted fetuses. This is only to evaluate if abnormal Doppler studies of uterine and umbilical arteries could serve as a good predictor of severe preeclampsia. Patients and methods: This study included 90 Pregnant patients divided into three groups (group (1)severe preeclamptic patients with AGA (Appropriate for Gestational Age), group (2) severe preeclamptic patients with IUGR (Intrauterine Growth Restricted) and group (3) control patients planned for cesarean section for presentation abnormalities or previous cesarean section). Umbilical artery and uterine artery Doppler were done for every patient before cesarean delivery and placenta and placental bed biopsies were sent post operatively for histopathological examination. Results: The preeclamptic AGA and IUGR group had significantly shorter mean gestational ages, lower mean birth weight and lower mean placental weights and NICU admission compared to control group. Histologically, the preeclamptic IUGR was characterized by significantly increased incidence of villous infarcts (70.0 % and 30% respectively, p<0.05), luminal obliteration of spiral arterioles (46.7 % and 13.3% respectively, p<0.05), villous fibrosis (56.7% and 33.3% respectively, p<0.05), perivillous hyalinosis . (56.7% and 63.3% respectively, p<0.05) and perivillous fibrin deposition (56.7% and 63.3% respectively, p<0.05) compared to the normal controls. The IUGR group had significantly shorter mean gestational ages, lower mean birth weight and lower mean placental weights compared to the AGA group (p<0.05). Histologically, preeclamptic IUGR was characterized by significantly increased incidence of villous infarcts (70.0 %, p<0.05) and luminal obliteration of spiral arterioles (46.7 %, p<0.05) compared to AGA group