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Abstract
Background and aim: Peptic ulcer is a chronic disease which impairs the quality of life and is associated with increased morbidity and mortality. Imbalance between gastro duodenal mucosal defense and aggressive factors are supposed to play an important role in pathophysiology of peptic ulcer. Objectives: This experimental study was designed to investigate the antiulcer role of silymarin, a bioflavonoid used in liver disease, in prophylaxis and treatment of indomethacin and cold restraint ulcer models. Ranitidine was used as a standard drug for comparison. Results: Rats subjected to indomethacin and cold restraint ulcers showed significant increase in volume and the mean ulcer score with decrease pH of gastric acid secretion. Indomethacin ulcer showed increase in Ach.induced contraction while the reverse occurred in cold restraint ulcer. Administration of silymarin and ranitidine for one week before or after induction of indomethacin and cold restraint ulcer significantly reduced the volume of gastric secretion and the mean ulcer score while pH was significantly increased. Silymarin and Ranitidine administration decreased response of isolated rat fundus to Ach. induced contraction compared to indomethacin ulcer control group. While in cold restraint ulcer the reverse occurred with an increase in Ach. induced contraction compared to cold restraint ulcer control. Conclusion: The obtained data of the present study showed that silymarin was comparable with ranitidine in prophylaxis and treatment of indomethacin and cold restraint ulcer models. This effect may be mediated through silymarin antioxidant activity.