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Abstract
To assess the value of speckle tracking-derived strain in detecting early LV systolic deformation abnormalities in both b-thalassaemia intermedia and b-thalassaemia major, who had been compliant to treatment since their infancy and whose m-mode derived ejection fraction and LV dimensions were normal, as well as to illustrate the pattern of LV systolic deformation in the two main b-thalassaemia phenotypes, and its possible difference from normal age-matched pattern.Methods The study population comprised 3 groups: group 1 included 26 patients with 1- thalassaemia major, group 2 included 24 patients with b-thalassaemia intermedia, and group 3 included 21 age-matched normal individuals. All subjects had arterial pressure measured, serum ferritin, and conventional echocardiography in addition to the evaluation of speckle tracking-derived LV strain and rotational mechanics. Results Systolic and diastolic arterial blood pressures were significantly lower in both 1- thalassaemia groups than in normal (P: 0.000), All enrolled individuals, including both 1-thalassaemic patients groups had normal ejection fraction. There was no statistically significant difference in LV cavity dimensions or indexed volumes among the 3 groups. The global radial and circumferential strain were significantly different among groups with values lower in both 1-thalassaemia groups than in the normal control group (P: 0.000) with no significant difference between the 2 b-thalassaemia groups (P: 0.6518). There was a significant difference in the peak LV twist, and peak systolic apical rotation (P:0.000 for both parameters), being lower in b-thalassaemia groups, with no significant difference between the 2 b-thalassaemia groups (P: 0.055), and (P:0.37088) for peak twist and peak apical rotation respectively. No significant correlation was found between serum ferritin and any of the speckle tracking parameters