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Abstract
The aim of the study is to detect the increase in proinflammatory cytokine (interleukin- 8) and marker of endothelial activation (soluble intercellular adhesion molecule- 1), as manifestation of transfusion-related immunomodulation in preterm neonates at different postnatal ages. Results: In group 1 neonates the post-transfusion levels of IL-8 was higher than the pre-transfusion levels with no statistical significance yet there was a trend. In group 2 neonates the post-transfusion IL-8 levels was higher than the pre-transfusion levels and the difference was not statistically significant. In group 1 & 2 neonates, there was no statistical significance between the pre- and post-transfusion sICAM-1 levels. There was a positive correlation between the post-transfusion level of IL8 and its level in packed red blood cells (PRBCs) bags in both groups. This correlation was significant in group 2 and was not significant, but yet there was a trend in group 1. And there was a significant positive correlation between post-transfusion levels of IL-8 and sICAM-1 in group 1 neonates.