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Abstract
The aim of this thesis is to prepare osmotic drug delivery system of Vinpocetine to solve its solubility and bioavailability problems.Chapter one aimed at formulating and evaluating the S-SNEDDS of VNP and then transforming it into tablet that act thereafter as the core for the osmotic system.Two systems were tried and the successful one which consists of 10% Maisine{u2122} 35-1, 50% Cremophor® EL, and 40% Transcutol® HP loaded with VNP was used. Every 0.25 gm of this system contained 2.5 mg VNP.Evaluation of VNP SNEDDS was performed by many means; assessment of the self-emulsification efficiency, equilibration at both ambient temperature and 4 {u02DA}C for 1 week, and then examination of the system for existence of turbidity, phase separation, or precipitation of VNP, determination of both the droplet size and polydispersity index (PDI), and examination of the nanostructure and surface morphology of nano-emulsions produced from the reconstituted liquid and S-SNEDDS by transmission electron microscopy (TEM).Adsorption to solid carriers by mixing in mortar using Aeroperl® as carrier produced free flowing powders. Many trials have been made to formulate the core tablet and finally C4 was selected as best core to be used further to produce osmotic tablets of VNP.The aim of chapter two was to formulate an osmotic system of VNP. A 3 2 * 2 1 full factorial design was selected for optimization of VNP formulation. The independent variables selected for this study were types of coat (X1) concentration of coats (X 2) and number of drills (X 3)