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Abstract
The chloroform fraction of the latex and methanolic extract of the aerial parts of Euphorbia cooperi N. E. Br., its chloroform and n-butanol fractions were tested for their cytotoxic activity on breast cancer (MCF7), hepatocellular carcinoma (HepG2), and cervix cancer (HELA) cells. The highest effect of all tested extracts was observed against the breast cancer (MCF7) while the least against the cervix cell line (HELA). Moderate activity against hepatocellular carcinoma (HepG2) was shown by the latex and n-butanol extracts. In vitro antioxidant effect of the methanol extract, chloroform and n-butanol fractions of the aerial parts was determined using DPPH scavenging method. The n-butanol fraction showed the highest antioxidant activity followed by the methanolic extract. The chloroform fraction showed the lowest antioxidant activity. Pretreatment with the methanolic extract and the n-butanol fraction of the aerial parts significantly showed an inhibition in the paracetamol-induced hepatotoxicity while pretreatment with the chloroform fraction of the aerial parts showed no significant effect which confirmed by histopathological studies