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Abstract
Ciprofloxacin hydrochloride given as oral tablet is rapidly and well absorbed from gastrointestinal tract (Campoli-Richard, 1988), its absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism (Ngwuluka et al., 2009). Maximum serum concentration are attained in 1 to 2 hours after oral dosing (Obi, 2009). The increase in the number of generics of ciprofloxacin hydrochloride can be attributed to increased prescription of ciprofloxacin hydrochloride. It would appear that for most infections, empirically and sometimes after laboratory investigations, physicians prescribe ciprofloxacin hydrochloride as the first drug of choice. The availability of different brands of the same drug places many prescribers in a difficult position over the choice of an {u2018}ideal{u2019} brand. This study was undertaken to evaluate the efficacy and justification of generic substitution of ciprofloxacin hydrochloride brands in the Egyptian market. Ciprofloxacin hydrochloride is an antibactericidal agent. It was first sold by Bayer Pharmaceuticals. There were just a few brands in the Egyptian market but recently many brands of ciprofloxacin hydrochloride have flooded the market. There is a growing concern about this situation. How can a patient know if buying a cheaper brand would be cost effective or not?.