الفهرس Only 14 pages are availabe for public view
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Abstract
Self-emulsifying drug delivery system has been proven to be a successful tool to improve the solubility and therefore bioavailability of lipophilic drugs. Upon dilution with the aqueous fluid and mild agitation the self- emulsifying components readily and quickly disperse into microemulsion. Tadalafil is a phosphodiesterase type 5 inhibitor, with an elimination half- life (T1/2) 17.5 hours and 2 hours for the onset of action. Tadalafil is a class II drug, with low solubility, thus having a bioavailability of approximated 30%. Overcoming the delayed onset of action as well as increasing the bioavailability was approached in this study