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Abstract
The original work of this thesis includes the study of the alkaline hydrolysis of 5-arylidenerhodanines with 20% sodium hydroxide solution to afford 3-aryl-2- mercaptoacrylic acids, which reacted with trichloroacetonitrile to give oxathiolane derivatives. The reaction of 2-mercapto-5-aryl-penta-2,4-dienoic acids with trichloroacetonitrile gave thiazole derivatives, also they reacted with Ü-arylazomalononitriles and bis-Ü-arylazomalononitriles to give hydrazono thiazol-4-one derivatives. Alkylation of 5-arylrhodanines with ethyl chloroacetate and phenacyl chloride afforded the S-alkylated derivatives which gave the arylidine-2,4- thiazolidinediones in the presence of triethylamine and benzaldehyde. The anticancer activity of some of the newly synthesized compounds was investigated and confirmed by molecular docking