الفهرس 
Prognostic significance of 1973 and 2004 WHO classifications of bladder cancer in non - muscle invasive (Ta and T?) urothelial tumors : A comparative histopathological and immunohistochemical study
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Abstract
from this study, we concluded that: Both WHO grading systems have prognostic significance. Although the new WHO 2004 grading system is more superior over the old 1973 WHO grading system as being significantly correlated with more prognostic factors including patients{u2019} age, presence of bilharziasis, presence of CIS, tumor size, tumor stage, T1 tumors sub-stage, and immunohistochemical expression of well-established prognostic markers (Ki-67 labelling index, p21 and MCM2 expressions). Both the 1973 WHO and the 2004 WHO classifications are effective in predicting tumor progression in NMIBC, but not in predicting tumor recurrence. SUb - staging of T1 tumors according to the level of invasion to the lamina propria and muscularis mucosa is an independent prognostic factor that correlated very well with both WHO grading systems and also proved to be a good predictor for tumor progression. Ki - 67 labelling index is a good predictor for tumor progression. P21 and MCM2 are good predictors for tumor recurrence