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Abstract
p27 is a negative regulator of cell cycle, considered a tumor suppressor gene and belongs to a family of cyclin-dependent protein kinase inhibitors. The aim of this work is to study the value & importance of p27 expression as a potential prognostic marker in breast invasive duct carcinomas (NST).The examined cases were immunostained by p27 & correlated with established prognostic factors of breast carcinoma (tumor stage, grade, lymph node status, ER, PR, HER2/neu, Ki-67 index). The recorded results show statistically significant relationship between diminished p27 expression and aggressive parameters of the examined tumors. So our conclusion is that p27 is a potential prognostic & predictive marker and may play a role in designing an individually tailored cancer therapy