الفهرس 
Biochemical changes of some markers and hormones in rats exposed to acetaminophen
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Abstract
The aim of the present study is to evaluate the protective role of vitamin C and /or vitamin E for detoxification of acetaminophen (APAP) in adult male albino rats. The study was designed to induce toxicity using a single oral dose of APAP (1g/kg rat body weight) then investigate vitamins protection. Eighty four male albino rats were divided into fourteen groups, each group consists of six rats: group (1) is the control group, group (2) administrated APAP, groups (3 to 5) took vitamins only (C), (E) and (C+E) respectively), groups (6 to 8) treated with vitamins before APAP administration (Cb , Eb and (C+E)b respectively), groups (9 to 11) treated with vitamins after APAP administration (C)a , (E)a and (C+E)a respectively), groups (12 to 14) treated with vitamins before and after APAP (C)b&a, (E)b&a and (C+E)b&a respectively). The studied biochemical parameters included b&a serum ALT and AST, total bilirubin, albumin, urea and creatinine levels. Hormonal determination of serum total testosterone and leptin levels were done using radioimmunoassay. Additionally, histological examinations of liver, kidneys and testes were done. Treatment with vitamin (C) as well as vitamin E (Ü- tocopherol) led to a significant attenuation in all the investigated items. Thus, vitamin (C) and (E) appear to be a promising agent for protection against APAP induced toxicity