الفهرس 
Postoperative Pain and Expression of Substance P, IL8 After the Use of Ketorolac Irrigant in Teeth with Symptomatic Irreversible Pulpitis with Apical Periodontitis (Clinical Trial)
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Abstract
Aim: The aim of this clinical trial was to assess the influence of ketorolac tromethamine versus sodium hypochlorite irrigant as a final rinse on, postoperative pain in patients with symptomatic irreversible pulpitis with apical periodontitis in single visit root canal treatment and periapical substance P and IL-8 level post-instrumentation and pre-obturation.
Methodology: Forty-four patients were included. After confirming the diagnosis clinically and radiographically, patients were assigned into two irrigant groups (n=22), 2.5% sodium hypochloriteand ketorolac tromethamine. The pain was assessed using the verbal rating scale (VRS) preoperatively, and postoperatively after 6, 12, 24 and 48 hours. All demographic, baseline andoutcome data were collected and statistically analyzed. Periapical blood samples (sample 1) were collected on post instrumentation, and periapical blood samples (sample 2) were collected pre-obturation. Quantification of substance P and IL8 was done by ELISA test.
Results: There was no statistically significant difference between the two groups regarding age, gender distribution, pre-operative pain and postoperative pain at 6 hours, 12 hours, 24 hours, 48 hours.There was no statistically significant difference in the levels ofIL8 and substance P between the two irrigant groups.
Conclusion: Sodium hypochlorite used as a root canal irrigant to reduce bacterial count could becontributedtothereductionininflammationandpostoperativepain.ThelevelofIL8andsubstance P showed no statisticallysignificant differencebetween thetwo irrigant groups.