الفهرس | Only 14 pages are availabe for public view |
Abstract The underlying precise mechanisms of NAFLD pathogenesis is “multiple hit” theory states that lipid accumulation initiates hepatic steatosis and subsequently triggers multiple insults acting together (hormones/adipokines from adipose tissue, inflammation, deregulated fat metabolism, lipotoxicity, oxidative stress, mitochondrial dysfunction, and genetic and epigenetic factors). NAFLD is becoming a global health concern which accounts for 25% prevalence worldwide due to the dominance of obesity, unhealthy dietary patterns and sedentary lifestyle patterns. |