الفهرس 
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Abstract
Background: All dental material should be tested for biological safety. Recently, there has been increasing in global public health concern associated with environmental contamination by metallic ions. Purpose: The purpose of this study is to assess the effect of Nickel containing metallic restorations on laboratory liver tests. Materials and Methods: Twenty patients were selected from Fixed Prosthodontics clinic, Faculty of Dentistry, Tanta University. Ten patients had no metallic restorations and were used as a control group (group I). The other had old porcelain fused to metal (PFM) or metallic restorations (group II). Liver, kidney and serum nickel (Ni) level tests were performed to all the patients at the beginning of the study. For group II, the old restorations were replaced with Zirconia. After six months from the insertion of the new restorations, liver, kidney and serum Ni level tests were repeated again. The data collected were statistically analyzed using Independent and paired samples T- test. Results: After six months from removal of the metallic restorations, there was significant increase in blood hemoglobin in group II (P-value =0.024) when compared with group I. There was also significant decrease in WBCs count (P-value=0.049) after treatment. There was significant decrease in liver and kidney function tests P-values were between (0.000 – 0.049). Serum Ni test was highly significant decreased after replacement of metallic restorations (P-value <0.000). Conclusion: within the limitations of this study, nickel released from metallic restorations has a negative feedback on human body health especially cases with multiple restorations and long durations.