الفهرس 
English summaryOnly 14 pages are availabe for public view
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Abstract
In this study, we illuminate for the first time the usage of migratory locusts (Locusta migratoria) as an insect model to comprehensively investigate the nanotoxicological influence of aluminum oxide Al2O3) nanoparticles at low doses on testes and evaluate the capability of a whole-body extract of American cockroaches (Periplaneta americana) (PAE) to frustrate the Al2O3 NPs-induced toxicity EDX analysis verified the bioaccumulation of Al in testicular tissues due to its liberation from Al2O3 NPs, implying their penetration into the blood-testis barrier. Remarkably, toxicity with Al engendered disorders of antioxidant and stress biomarkers associated with substantial DNA damage and cell apoptosis. Furthermore, histopathological and ultrastructural analyses manifested significant aberrations in the testicular tissues from the group exposed to Al2O3 NPs, exposing the overproduction of reactive oxygen species (ROS). Molecular docking analysis emphasized the antioxidant capacity of some compounds derived from PAE. Thus, pretreatment with PAE counteracted the detrimental effects of Al in the testes, revealing antioxidant properties and thwarting DNA impairment and cell apoptosis. Moreover, histological and ultrastructural examinations revealed no anomalies in the testes. Overall, these findings corroborated the potential applications of PAE in precluding the testicular impairment of L. migratoria and the conceivable utilization of locusts for nanotoxicology studies.