الفهرس | Only 14 pages are availabe for public view |
Abstract Objectives The aim of this study was to evaluate the left ventricular function in patients with idiopathic dilated cardiomyopathy (IDCM) by myocardial deformation imaging and detect its relation to the level of high sensitive cardiac troponin hs-(cTnT) in these patients. Background Myocardial mechanics of the left and right ventricles were recently used to evaluate global and regional myocardial function in different cardiac disease and would be especially useful in assessing idiopathic dilated cardiomyopathy (IDCM) patients. Cardiac troponin T (cTnT) serum levels can be measured as an easy-to-use indicator of myocyte damage. Recently discovered that TnT is a prognostic marker in individuals with idiopathic and secondary DCM whose prognosis is poor and who have abnormally high serum concentrations of TnT without an increase in serum creatine kinase (CK) concentrations. However, the limited sensitivity of the assay technique, places restrictions on the clinical application of the serum levels of cTnT. Recently, high sensitive cardiac troponin (hs-cTnT) became available and has proven to be an effective prognostic marker in CHF patients with IDCM. Patients and methods 32 patients where included in our study from patients diagnosed with (IDCM) who were referred to (Yacoub research unit, Menoufia university hospital, Egypt) between 2016 and 2020 for management, follow up or family screening compared to 25 healthy individuals. All the patients included signed the informed consent and approvals of Ethics Committee of Menoufia University Hospitals and were subgected to history taking, clinical examination, Electrocardiogram (ECG), echocardiogram, off‑line 2D strain analysis was performed by echocardiography for the assessment of strain and Strain Rate (SR) of the left and right ventricles, measuring serum hs-cTnT by using the Elecsys Troponin T High- Sensitive Immunoassay, and coronary angiography. (Coronary angiography, CT Coronary angiography or SPECT were done for some patients who were at moderate to high risk to exclude ischemic heart disease). |