الفهرس 
Frequency of hepatitis C virus infection in patients with pediatric inflammatory bowel disease in the new children’s university hospital, Cairo University
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Abstract
Introduction: Patients with pediatric inflammatory bowel disease (PIBD) are believed to be at an increased risk of Hepatitis C Virus (HCV) infection not only due to using of immunosuppressive drugs, but also because of repeated blood transfusion, many endoscopic and other invasive procedures needed to diagnose and effectively control the disease.
Aim of the study was to assess the frequency of HCV infection, in patients with PIBD at the New Children’s Hospital, Cairo University and identify the potential risk factors.
Patients and methods: This cross-sectional analytic study included 165 IBD patients between 1-16 years old of both sexes who were attending the pediatric gastroenterology clinic in the New Children’s University Hospital, Cairo University. All patients were screened for anti-HCV antibodies using ELISA. Factors related to IBD (severity, modalities of the treatment and invasive procedures) and to infection (blood transfusion history and family history of hepatitis and liver enzymes) were registered. The risk factors were evaluated by multivariate logistic regression analysis.
Results: present and/or past HCV infection was found in five (3%) of the IBD patients. The multivariate logistic regression to detect independent predictors of HCV +ve had statistically significant value with number of hospital admission related to IBD with p-value=0.002, odd ratio (OR) =1.467, and confidence interval (CI) =95% (1.145-1.879), and with number of hospital admission unrelated to IBD with p-value=0.024, OR=0.750 and CI95% (0.585-0.963).
Conclusion: The frequency of HCV infection in PIBD patients was 3%. Thus, the frequency of HCV infection in PIBD patients is similar to that in the normal population of the developing countries and it is strongly related to hospital admission due to IBD or non IBD causes