الفهرس 
Recurrence rate and survival analysis of neoadjuvant Chemo- Radiotherapy followed by surgery in patients with locally advanced cancer Cervix
Abstract:Only 14 pages are availabe for public view
 |  | from | 173 |  |  |
| | | from | 173 | | |
Abstract
Background: The standard of care (SOC) for treatment of patients with locally
advanced cervical cancer includes Concurrent Chemoradiotherapy (CCRTH)
followed by intracavitary brachytherapy. This modality represents a challenge for
the oncologists especially in countries with lack of brachytherapy centers. An
alternative method of treatment can be applied; radical hysterectomy following
neoadjuvant therapy, yet with limited efficacy data.
Aim of work: We aimed to investigate the loco-regional control rate and
survival data in those patients and compare it with those who received the SOC.
Patients and methods: A retrospective analysis involving patients with
pathologically proven cervical cancer, with FIGO stages IB2 till IVA who
presented to Clinical Oncology Department, Cairo University during the period
from January 2015 till December 2020. Data was retrieved from our medical
records, including demographic profile, pathological parameters, imaging workup, plan of management and time to occurrence of events.
Results: Data analysis showed comparative results between the two arms. Local
control was achieved by 83% on regular follow up. The loco-regional control rate
in patients who received definitive CCRTH followed by surgery was 75%, while
in those who received brachytherapy instead, was 85.3% (P-value= 0.24), there
was no significant difference in both groups regarding local control, OS and
distant metastasis.
Conclusion: In countries where there is lack of brachytherapy centers, Radical
Surgery can be offered as a modality of treatment following adjuvant therapy