الفهرس 
Assessment of quality of life in sickle cell disease patients
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Abstract
Background: Sickle cell disease is a chronic autosomal recessive illness characterised by the formation of crescent sickle-shaped red blood cells following deoxygenation, culminating in painful vaso-occlusive crises. Patients are subjected to a variety of pressures, including severe crises, frequent hospital visits, and blood transfusions. As a result, individuals suffer from physical, psychological, and social issues.
Objectives: To assess the quality of life among sickle cell disease patients using Child Health Quality-Parent Form 50 (CHQ-PF50) and Child Health Quality- Child Form 87 (CHQ-CH87) questionnaires and to determine the most affected domains. Methods: An analytical cross-sectional study conducted in Children Hospitals of Cairo University. One hundred and fifty patients were enrolled. Quality of life was assessed with the following questionnaires: (CHQ-PF 50) for parents of children aged (5-10 years), (CHQ-CF 87) for children (<10 - <18 years).
Results: The mean total score of CHQ-PF50 (182.8±17.7); CHQ-CF87 (289.1±
26.8). Global health was the most affected domain, followed by global behaviour item domain, according to the two questionnaires. In the CHQ-PF50 group, self-esteem was the least affected domain, whereas in the CHQ-CF87 group, behaviour was the least affected domain.
Conclusions: Patients with sickle cell disease have been proven to have a lower quality of life. In addition, all patients should have their quality of life assessed so that interventions concentrating on the domains affected can be implemented