الفهرس 
Prevelance of Hepatitis E Virus in A cohort of Imunocompromised Egyptian Patients
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Abstract
HEV infection represents one of the causes of chronic
hepatitis amongst the immunocompromised, particularly amongst solid
organ transplant recipients. Many HIV-positive cohort studies mentioned
that the seroprevalence of anti-HEV IgG ranged from 1.5% to 11.2%.
Aim of the study: This study aimed to assess the prevalence of hepatitis
E virus in a cohort of Egyptian immunocompromised patients( patients
with human immunodeficiency virus and liver transplantation recipients).
Patients and methods: This is a cross sectional study that included 150
adult subjects of both genders, recruited during the period from
September 2017 tıll February 2019). Subjects were divided into 3 groups:
group A included 50 LDLT recipients( recruited from liver
transplantation center at Al-Manial specialized hospital), group B
included 50 HIV patients( recruited from Imbaba fever hospital), and
group c included 50 control subjects (LDLT donors, recruited from liver
transplantation center at Al-Manial specialized hospital). Patients were
subjected to: routine labs, HIV viral load by PCR, ELISA and CD4 cell
count for HIV patients. HEV IgG by Enzyme Imunoassay (EIA) was
done. All patients undergone abdominal ultrasound and fibroscan.
Results: The mean age of the studied subjects was 40±12 years, with a
statistically significant male predominance (66.6%). HEV IgG was positive
in (33 subjects) of group A (22%), while in group B 11 subjects (7.33%) and
only 2 subjects (1.33%) in group C. In the subgroup of LTX, both age (
p=0.02) and creatinine level (p=0.04) were higher in patients with HEV IgG
+ve. However, the other variables including gender, duration of
transplantation, liver function tests, immunosuppressant drugs and liver
stiffness showed no statistically significant difference between patients with
HEV IgG +ve,compared to those with HEV IgG –ve. In the subgroup of
HIV, detectable HIV viral RNA (p=0.02) was significantly higher in
patients with HEV IgG +ve. However, the other variables including age,
gender,CD4 cell count, HIV viral load and fibrosis results by fibroscan,
showed no statistically significant difference between patients with HEV
IgG +ve,compared to those with HEV IgG –ve.
Conclusion: Prevelance of HEV is higher in immunocompromised patients
than in normal individuals. Thıs warrants thorough screenıng for HEV
ınfectıon in immunocompromısed patıents to avoid serious complicatıons.