الفهرس 
Anatomy of The Angle Of The Anterior ChamberOnly 14 pages are availabe for public view
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Abstract
Ocular hypertension (OHT) is a clinical condition characterized by elevated intraocular pressure (IOP), a normal visual field, and the absence of glaucomatous optic disc changes.
If left untreated, the cumulative probability of developing primary open-angle glaucoma (POAG) at 5 years is reported to be 9.5% in these patients. While the benefits of treatment with OHT medications have been well-documented, the continued loss of visual function in some patients with controlled IOP supports the role of vascular and hemodynamic factors in the pathogenesis of glaucomatous optic neuropathy.
So evaluation of changes in the ocular blood flow of OHT patients can provide clues about possible underlying factors that lead to development of glaucoma.
Vascular dysregulation of the optic nerve head and the peripapillary retina has been proposed for decades as a risk factor for the development and progression of glaucoma, one of the most common reasons of irreversible vision loss and blindness worldwide.
In this study we used optical coherence tomography (OCT) angiography, a novel noninvasive functional imaging technology, to measure vessel density and perfusion in various layers of the optic nerve head and the peripapillary retina.
OCT angiography allows selective investigation of perfusion in the area of a structural abnormality, which aids accurate diagnosis and may potentially improve our understanding of the pathophysiology of glaucoma and detection of glaucomatous progression.
The aim of this study is to measure optic disc perfusion and peripapillary retinal nerve fiber layer thickness in patients with ocular hypertension and in normal subjects by using optical coherence tomography angiography (OCTA).
Twenty patients with ocular hypertension (hypertensive group) and twenty normal subjects (control group) were enrolled in this study. The measurement of optic disc perfusion and RNFL thickness were obtained by AngioVue OCT (Optvue).
The results of this study demonstrated that there were decrease in optic disc perfusion and RNFL thickness in total peripapillary, superior hemi, inferior hemi, superior, inferior, nasal and temporal quadrants in patients with ocular hypertension than normal subjects.
In addition, there were negative correlation between IOP and optic disc perfusion and also negative correlation between IOP and RNFL thickness in patients with ocular hypertension.
We conclude from this study that OCTA can measure optic disc perfusion and RNFL thickness in peripapillary region and patients with ocular hypertension have OCTA changes than normal subjects.