الفهرس 
The Efficacy of Oral Ivabradine in Patients Presented with acute non ST-segment Elevation Myocardial Infarction (NSTEMI)5
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Abstract
Background
An elevated heart rate is an important determinant of ischemia and is linearly correlated with
cardiovascular morbidity and mortality. A systematic review/meta-analysis has been
conducted to identify gaps in evidence in ivabardine prescribing practice due to lack of
sufficient studies in this acute setting. Systematic review revealed no articles reported
ivabradine impact in this setting. Therefore, our study aims to evaluate the beneficial effect of
a heart rate reduction of oral ivabradine in patients presenting with non-ST-segment elevation
myocardial infarction (NSTEMI) during acute stage post percutaneous coronary intervention .
Methods
A total of 100 patients admitted to the emergency department, National Heart Institute, Cairo,
Egypt, were randomized into two groups as follows: group A: 50 patients with NSTEMI
treated with ivabradine (5mg twice daily) in addition to the conventional treatment; group B:
50 patients with NSTEMI treated with the conventional treatment only. Demographic data,
detailed history, clinical examination, chest pain onset, blood pressure, heart rate (HR),
temperature and respiratory rate, electrocardiogram (ECG) as well as echocardiography
and laboratory investigations were recorded. Patients were monitored for a period of 3-5 days
(acute stage)