الفهرس 
Evaluation of Pain Regression in Patients with Myofascial Facial Pain Treated by Dextrose Prolotherapy versus Local Anesthetic Injections: A Prospective Double-Blind Randomized Placebo- Controlled Clinical Trial
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Abstract
The efficiency of TPI for the treatment of MTrPs is well documented in the
literatures. Nevertheless, the comparison between various injectable solutions is
paramount with a view for determining the most effective one. Thus, it was the
aim of this study to assess and compare the treatment effects of dextrose
prolotherapy, saline, and mepivacaine injections for deactivating MTrPs within the
jaw muscles.
A total of 60 patients with active MTrPs within the jaw muscles were included
in this prospective study. The patients were randomly allocated to one of three equal
groups using computerized sequence generation. The mean age of patients was 33.6,
34.35 and 35.15 years and the mean duration of symptoms was 17.06, 8.61 and 21.67
months in the dextrose, saline and LA groups respectively. All patients were females
except one male in the dextrose group. For all patients, three consecutive weekly
rounds of treatment were performed; 3 treatment sessions at an interval of 2 days in
the first week, 2 treatment sessions at an interval of 3 days in the second week and
one treatment session at the end of the third week. Before treatment and at one week
and 12 weeks after the end of the treatment sessions, current and worst pain severity
was assessed by visual analog scale (VAS), degree of tenderness at the trigger points
(PPT) by algometry, and the MMO.
There was a significant improvement in current and worst pain severity at the 1
st
and 12th
post-injection weeks compared to those at the baseline in all the three
groups. The improvement in TrP tenderness as evident by the increase in PPT
values compared to those at the baseline was significant by the 1st post-injection
week and insignificant at the
12th post-injection week in the dextrose and LA groups, and insignificant
at both intervals in the saline group. In all the three groups, the MMO showed
statistically insignificant difference throughout the study intervals. The pain
relieving as evident by decreasing VAS and increasing PPT values was significant
in the dextrose and LA groups at the 1st post- injection week compared to saline
group. At the 12th post-injection week, the saline group showed statistically higher
MMO mean than that of LA group