الفهرس 
Effect of pre-emptive intravenous immunoglobulin administration on the incidence of septic episodes in pediatric burn patients: A randomized controlled study
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Abstract
Abstract
Background: Sepsis represents a major cause of morbidity and mortality in pediatric
burn patients as this patient sub-population comprises many factors affecting cellular
and humoral immunity, viz., depressed serum immunoglobulin G (IgG) levels due to
loss and immature synthesis, in this age group. Also, IgG levels’ deficiency
aggravates the risk for TSS development. Besides, the loss of skin integrity facilitates
colonization and subsequent infection and sepsis. Besides aggressive antimicrobial
administration, intravenous immunoglobulin is presumed to decrease sepsis and TSS
development through providing passive immunization for the patients at the time of
immunosuppression and neutralizing TSS-1 toxin if the patient developed TSS.