الفهرس 
Lung AnatomyOnly 14 pages are availabe for public view
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Abstract
Background: Pleural effusion in particular is considered a sign of an underlying pathology, so it is necessary to search for the cause and determine whether it is a benign cause or a malignant one as they differ in treatment and prognosis.
Aim of The Work: To assess the accuracy of contrast-enhanced CT chest to predict the nature of pleural effusion whether benign or malignant using the CT-based scoring system developed by Porcel et al. (1)
Patients and Methods: This study was a retrospective study that involved reviewing the contrast-enhanced CT chest done at the radiodiagnosis department in Ain Shams University Hospitals of 30 adult patients (age >18 years old) with unilateral or bilateral pleural effusion, and scoring it according to the Porcel et al (1) CT scoring system while being blinded to the final diagnosis. The total score was then compared to the biopsy or cytology of the patient to determine its accuracy.
Results: Analyzing the data showed that the highly significant item of the scoring system denoting malignancy was pleural lesion followed by lung masses, liver metastasis, abdominal masses, and absence of pericardial effusion. The cutoff value in our study was found to be total score >7 denoting malignancy with a sensitivity of 94.12%, a specificity of 100%, a PPV (positive predictive value) of 100, a NPV (negative predictive value) of 92.2 and AUC (area under curve) = 0.986. On the other hand, the cutoff value of the study done by Porcel et al (1) (≥7 denotes malignancy) gave a sensitivity of 94.1%, a specificity of 92.3%,a PPV of 94.12, a NPV of 92.31, and an accuracy of 93.33% in our study while in their study gave a sensitivity of 88%, a specificity of 94%, and AUC = 0.919.
Conclusion: This is a simple chest CT scan scoring system, which includes the evaluation of pleural nodularity or thickening, liver metastases, abdominal masses, lung nodules or masses, pleural loculations, pericardial effusions, and cardiomegaly. It can be used as a reliable tool that helps determine the differential diagnosis of pleural effusion yet does not replace cytology/biopsy. Further studies assessing this CT scan score are recommended.
Keywords:
contrast-enhanced CT chest, CT-based scoring system, benign pleural effusion, malignant pleural effusion.