الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 190 |  |  |
| | | from | 190 | | |
Abstract
Infertility affects approximately 8-12% couples around the world. The release of endocrine-disrupting chemicals into the environment has been linked to a decline in male reproductive health.
Bisphenol-A (BPA) has been classified as an endocrine disrupting chemical. It has a disruptor effect on endogenous hormones by inhibiting or stimulating or modifying them. It has antiandrogenic and estrogenic properties. High-dose BPA exposure in adult rats may compromise spermatozoa and disrupt the hypothalamic–pituitary–gonadal axis. It can also cause secondary hypogonadism and squamous metaplasia in prostatic epithelium. Bisphenol-A also causes cellular damage to protein and lipid structures by releasing ROSs in the tissues where it
accumulates.
Alpha-lipoic acid (α-LA) is a biological thiol antioxidant that reduces oxidative damage and boosts the levels of other antioxidants. It has been proposed that it could alleviate testicular oxidative stress, testicular injury, and lipid peroxides caused by BPA toxicity.
Naringin (N) is a flavone exists in citrus fruits, tomatoes, cherries, grapefruit, and cocoa. It was reported to have the ability to restore the normal testicular and epididymal structure in mice. It also reduced BPA-induced reproductive toxicity by adjusting the level of lipid peroxidation.
The aim of this study was to evaluate the ability of α-LA and N to ameliorate the disrupted effects of BPA on the prostate gland in adult albino rats.
Seventy-two young adult rats were used in the experiment and were divided equally and randomly into nine groups and subgroups