الفهرس 
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Abstract
Interstitial lung disease (ILD) comprises a group of diffuse inflammatory and fibrotic parenchymal lung diseases of varying etiologies, which are characterized by dyspnea, fatigue, and poor health-related quality of life. The incidence of ILD is increasing globally (Hutchinson et al., 2015).
Sleep disturbance negatively affects the comfort of patients with ILD (Bosi et al., 2019). Obstructive sleep apnea (OSA), characterized by airflow interruption during sleep due to repetitive pharyngeal narrowing , is one of the most common comorbidities seen in this group of patients (Fisher et al,. 2019). While OSA has been postulated to contribute to the pathogenesis of ILD through tractional or aspiration-related injury and intermittent hypoxia, it is equally reasonable that impaired respiratory mechanics and gas exchange in ILD may also predispose the individual towards developing OSA. (Khor et al., 2021)
The occurrences of OSA in patients with ILD have been a growing field of research over the past few years and several studies have reported the association of OSA in ILD. Timely diagnosis and management of sleep disorders in patients of ILD may help in better outcome of these patients and also improve the quality of life. (Kamgo et al., 2022)
This study is a cross-sectional observational study which included 69 patients who were diagnosed with diffuse parenchymal lung diseases. It was conducted in Chest department, Beni-Suef university hospital, in the period from December 2020 to May 2022.
The aim of this study was to evaluate the prevalence and predictive factors of SDB in ILD and analysis of the relationship between polysomnography (PSG) findings, pulmonary function, disease severity, parenchymal involvement, and sleep questionnaires ESS and SBQ.
The study showed that there is a significant prevalence of SDB especially OSA in patients of ILD. We found OSA in 24 patients in addition to increased RERA in 9 patients and NOD in 9 patients with overall 42 patients (60.9%) had SDB. And co-occurrence of SDB mainly OSA with ILD will further decrease quality of life and increases morbidity in these patients as in this study the group of patients with OSA had lower 6MWD and FVC. Moreover, there was a statistically significant higher level of oxygen desaturation (number, biggest, and average) with p-value <0.05 in cases with OSA than the cases without OSA.
The current study showed that the highest percent of OSA was found in IPF patients. Also there was a statistically significant higher percentage of OSA among males and older patients. Also weight, BMI and neck circumference were higher in OSA group but didn’t reach a statistical significance, with p-value >0.05. We observed sleep fragmentation and poor sleep quality in all studied patients and that was more obvious in patients with OSA.
There was statistically significant positive correlation with p-value <0.05 between AHI score and ODI, ESS scores, SBQ score, and left atrium diameter. But there was a statistical significant negative correlation between minimal so2 level and AHI. Also there was negative correlation between AHI and 6MWD, FVC, EPASP, and average oxygen but did not reach a statistical significance.