الفهرس 
Chapter (I): PsoriasisOnly 14 pages are availabe for public view
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Abstract
severe widespread skin lesions which may lead to disability and poor quality of life. Classic psoriasis, called psoriasis vulgaris or large plaque psoriasis, is the most common type. It is typically manifested as characteristic raised red plaques covered with silvery white scales, located on knees, elbows, scalp and in the lumbosacral area, although it can be more extensive. Clinical forms of psoriasis include chronic plaque psoriasis, guttate psoriasis, pustular psoriasis, unstable and erythrodermic psoriasis, scalp psoriasis, nail involvement and psoriatic arthritis.
Hepcidin, a peptide hormone which is mainly synthesized in the liver, is a regulator of iron metabolism The name ‗hepcidin‘ has originated from the place of synthesis in hepatocytes (hep) and its antimicrobial activity (cidin). Although hepcidin was first discovered in human urine and serum, most data on hepcidin expression, regulation, structure and function were obtained by in vitro approaches and studies in mice. Hepcidin was initially isolated from plasma ultrafiltrate and named liver-expressed antimicrobial peptide. Hepcidin synthesis is increased by infection and inflammation. This can cause iron dysregulation with hypoferremia and anemia related to inflammatory disease.
This study conducted on 20 patients suffering from psoriasis. In addition, 20 apparently healthy individuals of matched age, sex and
Summary and Conclusion
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BMI were chosen as a control group. Patients included in the study were subjected to detailed history taking including personal, disease and family history, complete dermatological examination and laboratory investigations including assessment serum levels of hepcidin, iron status (serum iron, ferritin, and TIBC). In this study, serum levels of hepcidin and ferritin were significantly higher in psoriasis patients than control subjects. Serum levels of iron and total iron binding capacity were significantly lower in psoriasis patients than control subjects.
Also this study revealed that There was significant relation between serum iron and onset of disease, patients with late onset had lower level of iron than patients with early onset 0.65±0.19 vs0.90±0.27 respectively (P value 0.035).