الفهرس 
Physical and chemical properties of resveratrolOnly 14 pages are availabe for public view
 |  | from | 178 |  |  |
| | | from | 178 | | |
Abstract
The use of dietary antioxidants to modulate the toxic side effects induced by insecticides is currently eliciting considerable interest. This study was undertaken to investigate the possible protective role of the antioxidant resveratrol (RSV) against oxidative stress induced by sulfoxaflor (SFX).
Male rats were administered sulfoxaflor orally in two doses of 187.7 and 375.5 mg/kg for four weeks (GPIII and GPV), respectively. In groups GPIV and GPVI, rats were treated orally with SFX at both doses and RSV (20 mg/kg).
Animals were sacrificed after 4 weeks of treatments. The protective role of RSV against the toxic effects of the SFX was evaluated by measuring the levels of ALT, AST, LDH, GGT, albumin, urea, creatinine, and total antioxidant concentration in serum blood. In addition, the oxidative stress induced by sulfoxaflor (SFX) was assessed by determining malondialdehyde (MDA), reduced glutathione (GSH), Glutathione disulfide (GSSG), and nitric oxide (NO) in liver and kidney tissues. The protective role of RSV was also evaluated by using histological and molecular studies.
RSV enhanced the levels of ALT, AST, LDH, GGT, albumin, urea, creatinine, and total antioxidant concentration. Moreover, rats treated with RSV indicated a decrease in the levels of MDA, GSSG, NO levels with an increase in GSH level.
The results indicated that RSV treatment improved histological structures of liver and kidney tissues and significantly reduced the DNA damage induced by sulfoxaflor. This protective effect of RSV could be attributed mainly to its ability to scavenge reactive oxygen species.
Key words: Sulfoxaflor, oxidative stress, resveratrol, liver, kidney, rat