الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 179 |  |  |
| | | from | 179 | | |
Abstract
This study was undertaken to investigate the ameliorative effect of liposomal curcumin in the recovery of pancreatic β- cells and its role in acceleration of the autophagal pathway in STZ-induced T1DM in adult male Sprague Dawley rats, through:
Determination of blood glucose, C-peptide and serum insulin. Determination of oxidant- antioxidant state (MDA &TAC) in pancreatic tissue. Real time-PCR analysis for the gene expression of mTORc1, EIF-2, ATF-6, CHOP, BSP, XBP-1, LC3II & AKT & becline-1 JNK and miRNA expression of mR29b & mRNA-137 P62 in pancreatic tissue (mir-21,mir-29 & mir-125b1-5p)in pancreatic tissue. Histopathological examination in pancreatic tissue. Immunohistochemical examination (LC3, Beclin-1, ATG16L) in pancreatic tissue.
Fifty Sprague Dawley male rats, were allocated into five equal groups each of 10.
This study was undertaken to investigate the ameliorative effect of liposomal curcumin in the recovery of pancreatic β- cells and its role in acceleration of the autophagal pathway in STZ-induced T1DM in adult male Sprague Dawley rats, through:
Determination of blood glucose, C-peptide and serum insulin. Determination of oxidant- antioxidant state (MDA &TAC) in pancreatic tissue. Real time-PCR analysis for the gene expression of mTORc1, EIF-2, ATF-6, CHOP, BSP, XBP-1, LC3II & AKT & becline-1 JNK and miRNA expression of mR29b & mRNA-137 P62 in pancreatic tissue (mir-21,mir-29 & mir-125b1-5p)in pancreatic tissue. Histopathological examination in pancreatic tissue. Immunohistochemical examination (LC3, Beclin-1, ATG16L) in pancreatic tissue.
Fifty Sprague Dawley male rats, were allocated into five equal groups each of 10.