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العنوان
Efficacy of Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis /
المؤلف
Sarah Elmohamedy Ghazy, Elmohamedy.
هيئة الاعداد
باحث / سارة المحمدى غازى المحمدى
مشرف / احمد محمد غنيم
مشرف / معتز محمد صبرى
مشرف / محمد مصطفى خاطر
الموضوع
Ophthalmology.
تاريخ النشر
2022.
عدد الصفحات
76 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب العيون
تاريخ الإجازة
15/2/2023
مكان الإجازة
جامعة طنطا - كلية الطب - Ophthalmology
الفهرس
Only 14 pages are availabe for public view

from 117

from 117

Abstract

Fungal keratitis is a serious cause of blindness worldwide, especiallyin developing countries. The risk factors are vegetative trauma, contact lensuse and contact lens solution, ocular surface disease, topical steroid orantibiotic use and immunosuppressive systemic states, and so forth [1, 2].Fungal keratitis has a poor prognosis because available antifungaldrugs are limited by poor penetration, limited spectrum, and surface toxicity.In the past, therapeutic keratoplasty (TPK) was usually used to treatrecalcitrant fungal keratitis, but there were some limitations, such as lowsuccess, severe complications, and decreased availability of donor corneas,especially in developing countries [3, 4].Recent studies indicate that intrastromal injection of antifungal drugscould better control infection by increasing drug concentrations at theinfection site [4-6].Corneal debridement has been used for relatively superficial lesions tocontrol infection by removing necrotic tissue containing toxic debris,pathogens, and inflammatory cells products that could further damagecorneal tissue and improving the penetration of topical medicine [7].