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Abstract Fungal keratitis is a serious cause of blindness worldwide, especiallyin developing countries. The risk factors are vegetative trauma, contact lensuse and contact lens solution, ocular surface disease, topical steroid orantibiotic use and immunosuppressive systemic states, and so forth [1, 2].Fungal keratitis has a poor prognosis because available antifungaldrugs are limited by poor penetration, limited spectrum, and surface toxicity.In the past, therapeutic keratoplasty (TPK) was usually used to treatrecalcitrant fungal keratitis, but there were some limitations, such as lowsuccess, severe complications, and decreased availability of donor corneas,especially in developing countries [3, 4].Recent studies indicate that intrastromal injection of antifungal drugscould better control infection by increasing drug concentrations at theinfection site [4-6].Corneal debridement has been used for relatively superficial lesions tocontrol infection by removing necrotic tissue containing toxic debris,pathogens, and inflammatory cells products that could further damagecorneal tissue and improving the penetration of topical medicine [7]. |