الفهرس 
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Abstract
Bronchiectasis is a chronic respiratory disease in which the triplet of airway infection, inflammation and destruction is implicated. The pathogenic insults result in intense airway inflammation leading to persistent airway destruction. Apart from high-resolution computed tomography spirometry has constituted the cornerstone of lung function tests which have been applied for assessment of bronchiectasis. Of lung function tests, spirometry (particularly the parameters reflecting large-airway disorders) is the mainstay assessment tool for respiratory diseases. Impulse oscillometry is a non-invasive technique which could, by analyzing the mechanical waves superimposed upon respiratory maneuvers, provide global information regarding the airway resistance. It has been reported that IOS may sensitively discriminate small airway disorders in asthma chronic obstructive pulmonary disease interstitial lung disease and cystic fibrosis. The aim of work of the current study was to investigate the diagnostic utility of impulse oscillometry and its correlation with radiology and disease severity in patients with bronchiectasis. To elucidate these aim 40 patients with bronchiectasis diagnosed by HRCT, recruited from the outpatient clinic and admitted in Chest Department, Tanta University Hospitals. Such patients were classified into two groups, according to Bronchiectasis Severity Index (BSI): group I: Included 20 patients with mild to moderate bronchiectasis. group II: Included 20 patients with severe bronchiectasis. The mean age in group I was 46.55±10.04 years and in group II was 52.65±8.39 years. There were 45% males in group I and 50% in group II. The mean weight was 78±11.50 kg in group I and 58.45±9.50 kg in group II with a statistical difference in between. The mean duration of disease in group I was 6.368±2.05 years and in group II was 9.25±3.02 years. As regard to medication, the most common medication used in group I was Inhaled corticosteroids in 35% followed by Theophylline in 30%, in group II the most common medication used was Mucolytics in 35% followed by Theophylline in 30% with high statistical difference in between the two groups. The mean MEF 50% was 75.75±9.1 in group I and 42.42±8.3 in group II with high statistical difference in between. The mean FEV1 % predicted was 65.890 ±3. 5 in group I and 75.92 ±13.2 in group II with a significant difference in between. The mean FEV1/FVC % was 16.75 ±4. 5 in group I and 79.09 ±5.25 in group II with a significant difference in between. The mean R5% predicted was 186.62 ±10 in group I and 291.75 ±11.8 in group II with a significant difference in between. There was a significant positive correlation in between HRCT score and each of FEV1 L, FEV1 % predicted, FVC (%) but there was a significant negative correlation in between HRCT score and MEF 75%, FEV1/FVC %. There was a significant positive correlation in between HRCT score and each of AX, R5% predicted, R5 actual, R20, X5. There was a significant correlation in between FEV1 L and each of R5% predicted, R5 actual and AX. MEF 50% had a significant correlation with R5% predicted, R5 actual, R20 and AX. Also, there was a significant correlation in between FEV1 % predicted with R5% predicted, R5 actual, and AX. There was a significant correlation in between FEV1/FVC % with R5% predicted, R5 actual, R20 and AX.