الفهرس 
The Association between The DNA Repair Genes Variants XRCC1 c. 1196A>C andMLH1?93G>A&c. 655A>G with Colorectal Cancer Risk
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Abstract
Background: Many studies discussed the association between
DNA repair gene polymorphisms and colorectal cancer (CRC) risk
(Wang et al., 2015), but produced controversial results. The
heterogenicity of the results in various ethnic populations may due to
differences in lifestyle, environmental factors, and genetic predisposition
(Namvaran et al., 2011; Liang et al., 2017).
Objective: To assess the role of the DNA repair gene variants
XRCC1 c. 1196 A>C and MLH1 −93G>A & c. 655A>G in respect to
CRC susceptibility in Egyptian patients.
Methods: Eighty CRC patients and 80 apparently healthy subjects
were tested for the DNA repair gene variants XRCC1 c. 1196 A>C and
MLH1 −93G>A & c. 655A>G by Taqman Real-Time PCR.
The results: No statistical significant association was found in the
genotype distribution of the studied three variants (XRCC1 c. 1196 A>C and
MLH1 −93G>A & c. 655A>G) between the CRC cases and the control
group. A statistical significant association between the MLH1 −93G>A
genotype and both the site of the tumor and the lymph node staging (N), a
part of TNM staging, has been demonstrated with a P-value of (0.025 and
0.016), respectively.
Conclusion: The results of this study suggest that the DNA repair
genes variants XRCC1 c. 1196 A>C and MLH1 −93G>A & c. 655A>G
have no statistical significant association with CRC in Egyptian patients