الفهرس 
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Abstract
Liver cirrhosis is an important cause of morbidity and mortality as a consequence of continuous liver injuries. Cirrhotic patients need frequent visits and multiple hospitalizations for management of cirrhosis or its complications. Lipids are essential component of biological membrane, free molecules and metabolic regulators that control cellular function and homeostasis. The liver plays a key role in the metabolism of plasma lipids and lipoproteins. It receives fatty acids and cholesterol from peripheral tissues and diet, packages them into lipoprotein complexes and releases these complexes back into circulation. chronic liver disease due to various causes are often associated with reductions in plasma TG and cholesterol level due to reduced lipoprotein biosynthetic capacity. As majority of endogenous cholesterol is synthesized in the hepatic microsomes, synthesis and metabolism of cholesterol is impaired in chronic liver disease resulting in a decrease in plasma levels. Severe metabolic impairment in cirrhosis can produce a worsening of the serum lipoprotein pattern. Studies suggest that the usage of lipid profile as prognostic indicator in patients with advanced liver disease due to the relation between cholesterol levels and its fractions reduction and the Child-Pugh score and the MELD (Model for End Stage Liver Disease). This study aimed to evaluate the lipid profile via assessing triglyceride (TG), total cholesterol, very low-density lipoprotein, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) in cirrhotic patients and to determine the relationship between lipid profile level and severity of liver cirrhosis. This was cross sectional study, conducted at Sohag university hospital, department of Tropical medicine and Gastroenterology, on adult cirrhotic patients divided into two groups: (Cirrhotic group (N=60), Control group (N=42)(, during a period of six months.
The main results of the study revealed that:
The most common etiology for the liver cirrhosis in studied group was HCV while in control patients most of them were negative serology .The mean value of total cholesterol, TG, HDL, LDL and VLDL were significantly lower in cirrhotic group as compared to control group. There were significant difference in HDL level between cirrhotic patients with child plugh A, B and C (p value <, 05). While in other parameters, there were no significant statically difference in child A, B and C between patient with hepatic condition. There were significant difference in total cholesterol and HDL level between cirrhotic patients with MELD<10, MELD (11-18), MELD (19-24) and MELD>25(p value <, 05). While in other parameters, there were no significant statically difference.
Based on our results we concluded that the amount of decrements measured in the levels of serum total cholesterol, LDL, and HDL in patients with cirrhosis is related to the disease severity and mortality in cirrhosis so, we recommend for further studies on larger patients and longer period of follow up to emphasize our conclusion.
CONCLUSION
Lipid profile abnormalities are common in patients with cirrhosis of liver and also differ according to severity of the disease.
RECOMMENDATIONS
Further large population studies are needed to determine the predictive values of lipid profile to estimate the extent of liver damage in cirrhotic patients.
Multicenteric study is needed.