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Abstract
Introduction: Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are two different types of eczematous skin inflammation that affect quality of life. Osteopontin (OPN) is an acidic phosphoglycoprotein with various biological functions. It is secreted by several tissue types and different cells including immune cells. Aim of work: The aim of this study is to compare serum levels of OPN in patients with ACD and AD versus normal controls, attempting to verify the potential role of OPN in the pathogenesis of these two diseases. Methods: Twenty five patients with ACD, twenty five patients with AD and twenty five age and sex matched healthy controls were enrolled in the study. OPN was detected in serum using ELISA technique. Results: Serum OPN levels were significantly higher in patients with ACD and AD than that of controls (P = 0.001). However, there were no significant difference in serum OPN levels in between atopic dermatitis and allergic contact dermatitis (P = 0.467). Conclusion: Similarly elevated serum OPN levels in both cases of ACD (in which OPN has a well-recognized role in its pathogenesis) and in AD, indicates the possible crucial involvement of OPN in the pathogenesis of AD the same way it is involved in the etiology of ACD. It seems that OPN exerts its role mainly through modulation of T helper cell-mediated immunity