الفهرس Only 14 pages are availabe for public view
 |  | from | 192 |  |  |
| | | from | 192 | | |
Abstract
Background: Neuropathy, a common complication of diabetes mellitus, is generally considered to be related to duration and severity of hyperglycemia. Diabetic neuropathies are nerve disorders associated with diabetes, which affect approximately half of all diabetes patients. The most common complication of diabetes is caused by hyperglycemia which can damage nerve fibers throughout the body. TLRs (Toll-like receptors) are family of pattern recognition receptors responsible for the initiation of inflammatory and immune response. Purpose: The aim of this study was to assess the diagnostic values of TLR4 as protein biomarkers of diabetic neuropathy. Method : This study will be conducted to 60 type 2 diabetic patients that will be randomly selected from the outpatient clinic of National Institute of Diabetes and Endocrinology (NIDE) and 20 healthy subjects. These type 2 diabetic patients will be classified into 2 groups: group (1):(30) type 2 diabetic patients without neuropathy. group (2) :(30) type 2 diabetic patients with neuropathy. group (3) (20) healthy control group matched for age, sex and socioeconomic classes. All groups will be subjected to: Full history taking (age, sex, duration of diabetes).clinical examination including ( weight, height, blood pressure)Lab investigations including: Fasting blood Sugar , Glygcosylated hemoglobin , Kidney function ,liver function Lipid profile .In addition to the routine investigation the followings serum biomarkers will be studied :Toll like receptor 4 by ELISA Kit ,and Hs-CRP by ELISA kit. Result :To assess the diagnostic values of TLR4 as biomarker, here we detected its level in peripheral blood from normal controls, type 2 diabetic and DPN subjects. Here TLR4 level increased significantly in DPN compare with both diabetic and control subjects. The level of CRP was also raised significantly and correlated with TLR4 level