الفهرس Only 14 pages are availabe for public view
 |  | from | 116 |  |  |
| | | from | 116 | | |
Abstract
The transition of a normal cell to a tumor cell involves large number of genetic changes and cell cycle instability. Additionally, the wide pharmacological activity of benzoxazepine nucleus and its contribution to the controlling mechanisms in cell cycle, promote us to synthesize new two series of 1,4 benzoxazepine 4- substituted butyl belonging to 3,5-dione and 5-oxo-3-phenyl derivatives which have a potential for antitumor activity. Twenty compounds were synthesized and eleven were chosen by National Cancer Institute, Bethesda, Maryland, USA for screening their in vitro antitumor activity against 60 cell lines