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Abstract
Background: Nephrotic syndrome (NS) is the most common renal disease of childhood with normal renal function. It usually responds to steroid therapy; however, the majority of children relapse, resulting in prolonged and repeated courses of steroid therapy. Vitamin D is a vital component of bone metabolism and calcium homeostasis, and its deficiency cause rickets, osteomalacia and hypocalcemia. Maintenance of adequate levels of vitamin D is recommended to maintain good bone health and other organ systems of NS patients.The study aimed to assess serum 25(OH)D level in children with NS, compare its level with healthy age and sex-matched controls and compare its level in different types of NS. Patients and methods: It was a cross-sectional study for measuring 25(OH)D levels in 60 patients with nephrotic syndrome (NS) who were recruited from the children hospital, Faculty of medicine, Cairo university. Sixty apparently healthy children randomly chosen from the children coming to the general clinic in the children hospital to be compared as controls. The patients underwent history taking, clinical evaluation and routine laboratory investigations. Serum 25-hydroxyvitamin [25(OH)D] was measured using enzyme linked immune sorbent assay (ELISA) technique. Results: Serum 25(OH)D was significantly lower in NS patients than control group (p<0.001). Serum 25(OH)D was significantly lower in steroid resistant nephrotic syndrome (SRNS) patients than the other 2 groups steroid sensitive nephrotic syndrome (SSNS) and steroid dependent nephrotic syndrome SDNS p<0.001