الفهرس 
Title :Formulation and evaluation of injectable in-situ forming vesicles
ContantsOnly 14 pages are availabe for public view
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Abstract
Parenteral controlled release formulations offer several advantages over conventional dosage forms. They are released over extended period and hence improve the patient{u2019}s compliance and reduce the need for follow-up care. They maintain a constant drug plasma concentration thus the total dose can be reduced. They localize delivery of drugs and hence systemic exposure of the drug can be reduced. Vesicular systems are innovative means of delivering drug in controlled manner to enhance bioavailability and prolong their therapeutic effect. Microspheres and nanovesicles as liposomes and niosomes are common systems used as carriers to encapsulate an active drug. The properties of these systems can be varied to maximize their therapeutic efficacy leading to increased absorption, efficacy and stability and reduced toxicity of the active ingredient. Niosomes are examples of vesicular systems with amphiphilic nature that are well characterized for favorable permeation of drugs through biological membranes. They are capable of delivering the drug in a controlled manner to augment bioavailability and extend the therapeutic effect. Niosomes are superior to other micro and nano-encapsulation technologies through the higher stability of non-ionic surfactants compared to phospholipid molecules used in liposome formulations. Niosomes possess longer shelf-life than other nanocarrier systems. They are stable at room temperature and exhibit less light susceptibility