الفهرس 
Therapeutic role of mesenchymal stem cells in carbon tetrachloride- induced hepatic pathogenesis in the adult male albino rat
الدور العلاجى للخلايا الجذعية ضذ السمية الكبدية المحدثة برابع كلوريد الكربون في الفأر الألبيض البالغOnly 14 pages are availabe for public view
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Abstract
Cirrhosis is defined as a diffuse process inducing fibrosis and nodule formation. It is the final changes of the fibrogenesis consequent to chronic liver injury. Hepatotoxicity was induced in this study by injection of carbon tetrachloride (CCl4) subcutaneously at a dose of 0.2 ml/kg body weight twice weekly for four weeks and eight weeks durations. The rats were divided into eight groups ( n=10 rats each). Mesenchymal Stem cells (MSC) were injected into the tail vein only in two groups at a dose of 1x106 stem cells labeled with PKH26 dye in 1 ml phosphate buffer saline. Two groups injected with CCl4 were left to observe the effect of spontaneous recovery. liver specimens were examined by both light and transmission electron microscopic methods. Different levels of liver enzymes (ALT, AST and GGT) were measured. This study revealed that intravenous injection of MSC was more effective in rescuing liver failure than spontaneous recovery