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Abstract Langerhans cell histiocytosis (LCH) refers to a group of disorders characterized by langerhans cell proliferation, infiltration, and granuloma formation leading to organ dysfunction with diverse clinical presentation. Positron emission tomography/computed tomography is a useful tool to assess known LCH lesions and rule out the presence of other organ infiltration and to provide a reference basis of classification, staging, treatment plan, and evaluation therapy effect. FDG PET/CT not only provides the characteristics of lesions in CT scan, but also finding the lesions activity FDG uptake |