الفهرس 
Evaluation of 2survivin3 expression in urothelial carcinoma of the bladder :Histopathological and immunohistochemical study
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Abstract
Evaluation ofsurvivin immunohistochemicalexpression in bladder urothelial carcinoma and non-neoplastic bladder urothelium and correlation of survivin expression with various pathological parameters. Immunohistochemical staining for survivin was performed on paraffin-embedded sections of 40 cases of bladder urothelial carcinoma that underwent transurethral resection (14 cases) or radical cystectomy with bilateral pelvic lymphadenectomy (26 cases)together with nine sections of non-neoplastic bladder urotheliumfrom archives of Pathology department, Kasr Alainy, faculty of medicine, Cairo university in the period from March 2015 through February 2016. Expression of survivin in >10% of tumor cells was described as positive. Positive survivin expression was detected in twenty seven cases (67.5%) of urothelial carcinoma while all non-neoplastic bladder urothilal sections showed negative expression with statistically significant difference (p value =0.00). There was a significant association between survivin expression and the histological grade (p value= 0.043), the presence of invasion of the muscle proper (p value= 0.015) and the presence of nodal metastasis (p value= 0.045).Higher frequency of survivin expression was associated with higher pathological stage of the tumour (T), presence of tumour vascular emboli and perineural invasion but with no statistically significant difference.There was no significant association between survivin expression and tumour size, histological differentiation and associated bilharzial infestation among studied cases