الفهرس 
Oxidative stress in children with beta thalassemia and its role in neurological complications
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Abstract
Involvement of the nervous system in B- thalassemia patients has been reported by several studies and oxidative stress might play a role in the development of such neurological complications. To assess the prevalence of the global cognitive dysfunction and peripheral neuropathy in beta thalassemia patients, oxidant and antioxidant status in these patients and its relation to the studied neurological abnormalities. This study included 60 patients with Ý-thalassemia with mean age 19±4.9 and ranged from 12 to 27 years); (30 thalassemia major (TM group) and 30 thalassemia intermedia (TI group) regularly attending the pediatric hematology clinic, New children hospital, Cairo university and 30 healthy children of comparable age and sex was taken as control group. Serum ferritin, malondialdehyde (MDA), paraoxonase (PON), Nitric oxide (NO) and total antioxidant (TAC) were performed at enrollment. Stanford binet Intelligence scale was used for assessment of cognitive function and motor nerve conduction velocity (NCV) was performed to median, ulnar and peroneal nerves. Mean NO was 14.34±5.86um/ml, mean MDA was 4.5±1.6no/ml, the mean TAC was 1.6±0.5um/l, mean PON was 108.695±39.06 u/ml. Mean MDA was lower and mean NO, TAC, PON1 were higher in the control group compared to patients{u2019} groups (p<0.01 for all values). Nineteen (31.6%) patients had neurological features, 32 (53.3%) had impaired cognition. The most frequent abnormal finding in NCV was a reduction in the amplitude of compound muscle action potential CMAP of the peroneal nerve in 28 46.7% patients